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The main study was double blind. Efficacy of olanzapine in the treatment GAD was assessed by the patient's self-report using Clinical Global Impression (CGI) scale, and by the investigator performing CGI analysis, using baseline, post-randomization and 3 months post-randomization.
Results: In both study arms, all patients responded well to the initial treatment and showed marked improvement over the baseline. changes in patient ratings are shown (A-C).
Among the 24 responses (24 patients) to treatment with olanzapine in the study arm, at both baseline and 3 months post-treatment, there was no significant difference between the groups in overall score on the order olanzapine online CGI (p values of.02 and.02) or the rating of changes in Global Impression (p values of.08 and.09). Furthermore, at 3 months post-treatment, the CGI score in patients treated with olanzapine was significantly higher than that of the patients treated with placebo in both the olanzapine and placebo groups (p values of 1.28 and 2.52, respectively, for baseline 3 month post-treatment). No significant differences were observed among the various post-treatment values of patients' self-report about the efficacy of olanzapine in treatment GAD.
Conclusions: The present trial confirmed efficacy of olanzapine in treating adult outpatients with GAD a CGI score of 1 to 16. Treatment with placebo or olanzapine did not significantly affect the rating of changes in global impression or rating of the severity depression (from baseline to 3 months and from year 2). At 3 months post-randomization, olanzapine patients showed better global assessment of improvement in the depression and treatment outcomes.
Souciant M, Niaura-Marra S, Rizzo C, Mazzoni G, Caprioli M (2005). The relationship between antidepressant effect of memantine and other NMDA receptors its pharmacological profile, in a randomized controlled trial. Biol Psychiatry. 2005 best online pharmacy in canada Apr;56(4):341–50. Epub Jan 14. In a randomized controlled trial, memantine was shown to induce a rapid antidepressant effect on mood and Maxitrol ointment over the counter
affect which was sustained for many months in patients taking memantine monotherapy. The results are consistent with hypothesis that NMDA receptors are implicated in the process of antidepressant action.
The mechanism by which memantine induces its rapid antidepressant actions is unknown. The present results highlight requirement for investigation of potential synergistic effects monotherapy, such as niacin, with memantine in alleviating depression. Antidepressants can reduce the severity of depression in several ways, including a decrease in severity at the end of first week that is followed by a steady increase above baseline. However, memantine also displays both an antidepressant effect and a rapid recovery. The present results show that rapid mood improvement (that peaks at the beginning of third week) is not limited to patients who receive memantine monotherapy, but also is seen with other drugs (with a similar therapeutic index) that have different mechanisms of action. These results may guide development of drugs that reduce the severity of depression in a different way from that by which memantine does.
Kelham E, Mazzoni G, Caprioli M, Deiana A, C (2005). The impact of antidepressant effect memantine on the clinical symptoms of depression in patients who had been responders to a placebo treatment. J Gerontol B Psychol Sci Med Sci. 2005 Feb;65(2):S21-9.
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Generic olanzapine vs zyprexa for major depression: a meta-analysis, British Journal of Psychiatry, 2003, vol. 180 (pg. 539 - 44 ), vol.(pg. 35. Reif SJ Leucht G Hofer K Schlesinger S Muhleberger H Giering H, et al. Effectiveness, tolerability, safety and cost-effectiveness of antidepressants in major depression: a systematic review, Annals of Medicine, 2007, vol. 32 (pg. 1 - 17 ), vol.(pg. 36. Hofer LJ Reif S Where to buy zoloft in the uk
Ersberg H Muhleberger Giering The efficacy of various antidepressants in treating major depressive disorder: a meta-analysis, European Psychiatry, 2002, vol. 22 (pg. 115 - 24 ), vol.(pg. 37. Giedd J Fokker F de Vries JH Meerkerk J Grievel A van der Gaag HM Delespaul MP The European Network of Clinical Trials (ENICT)—proportion, treatment costs and side effects of standard pharmacotherapy in depression: a systematic review, BMC Medicine, 2002, vol. 2 pg. 34, vol.pg. 38. Giedd J Meerkerk Fokker F van der Gaag HM Zijnhoven M Meerkerk H Antidepressant therapy in major depression: a systematic review of randomized controlled trials, Annals Medicine, 2004, vol. 34 (pg. 10 - 1 ), vol.(pg. 39. Giedd J Meerkerk Schunemann G van Zijnhoven M Gelderen Y Delespaul MP A systematic review of the costs and efficacy antidepressant drugs in primary care clinical trials, Annals of Medicine, 2005, vol. 37 (pg. 731 - 40 ), vol.(pg. 40. Sadeghi F Shariat AA Vartian S Canada drug center free shipping
Hassan N Stylianou A, et al. Low-cost, low-risk psychotherapy for major depression: study protocol a multicenter, randomized, double-blind, placebo-controlled three-month open-label study, Depression and Anxiety, 2005, vol. 21 (pg. 889 - 98 ), vol.(pg. 41. Miller BL Schapira R O'Halloran K Lasko The efficacy of olanzapine in a cohort adults with Buy valtrex in canada
depression: findings from the olanzapine safety and tolerability extension trial (SUNICET), Journal of Clinical Psychopharmacology, 2005, vol. 21 (pg. 699 - 617 ), vol.(pg. 42. Schunemann G Jornet F Veron P Van der Gaag HM Muhleberger H The cost-effectiveness of psychotropic drugs for major depression: a meta-analysis, Archives of General Psychiatry, 2004, vol. 62 (pg. 593 - 99 ), vol.(pg. 43. Degenhardt LA Steganti A Hofer K Meerkerk J Ersberg H Muhleberger A comparison of the effects trazodone, sertraline and milnacipran as monotherapy: the monotherapy comparison subgroup, Journal of Affective Disorders, 2007, vol. 128 (pg. 165 - 76 ), vol.(pg. 44. Giedd J Delespaul MP Ersberg H Jornet F Stärkelberg R Van Zijnhoven M Randomized comparison of zoloft with an amphetamine in major depression: a multicenter, randomized double-blind comparative trial, Annals of Medicine, 2006, vol. 38 (pg. 605 - 11, vol.pg. 45. Ersberg H van Zijnhoven M Hofer K Muh))))))))))
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